Sesamol ameliorates high-fat and high-fructose induced cognitive defects via improving insulin signaling disruption in the central nervous system
Author:
Affiliation:
1. Laboratory of Functional Chemistry and Nutrition of Food
2. College of Food Science and Engineering
3. Northwest A&F University
4. Yangling
5. China
Abstract
The present study demonstrated that sesamol prevents high-fat and high-fructose diet induced systemic insulin resistance and cognitive defects via stimulating PI3K/Akt signaling, improving ERK/CREB/BDNF cascades, and preserving mitochondrial function.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
General Medicine,Food Science
Link
http://pubs.rsc.org/en/content/articlepdf/2017/FO/C6FO01562J
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