Synthesis of 2,4-diarylated pyrimidines enabled by Ni-catalyzed C–sulfone bond activation-Reference-Cited by-同舟云学术

Synthesis of 2,4-diarylated pyrimidines enabled by Ni-catalyzed C–sulfone bond activation

Published:2023 Issue:3 Volume:10 Page:645-650
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhang Qian¹²,Zhang Wei¹,Cui Ruoyan¹,Zhang Yang¹,Niu Dawen¹^ORCID

Affiliation:

1. Department of Emergency, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital and School of Chemical Engineering, Sichuan University, Chengdu, China

2. Sichuan Institute of Edible Fungi, Shizishan Road No. 4, Jinjiang district, Chengdu, China

Abstract

The readily available pyrimidinyl sulfones, in which the C–S bond is cleaved selectively, could serve as electrophiles in the Ni-catalyzed cross-coupling reactions to prepare 2,4-diarylated pyrimidines under mild conditions with a broad scope.

Funder

West China Hospital, Sichuan University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D2QO01935C

Reference60 articles.

1. Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration

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3. Synthetic Entries to and Biological Activity of Pyrrolopyrimidines

4. Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

5. Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer

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