Effect of isouronium/guanidinium substitution on the efficacy of a series of novel anti-cancer agents-Reference-Cited by-同舟云学术

Effect of isouronium/guanidinium substitution on the efficacy of a series of novel anti-cancer agents

Published:2018 Issue:4 Volume:9 Page:735-743
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Previtali Viola¹²³⁴⁵,Trujillo Cristina¹²³⁴⁵^ORCID,Amet Rebecca⁶²³⁴⁵,Zisterer Daniela M.⁶²³⁴⁵,Rozas Isabel¹²³⁴⁵^ORCID

Affiliation:

1. School of Chemistry

2. Trinity Biomedical Sciences Institute

3. Trinity College Dublin

4. Dublin 2

5. Ireland

6. School of Biochemistry and Immunology

Abstract

Considering our hypothesis that the guanidinium moiety in the protein kinase type III inhibitor 1 interacts with a phosphate of ATP within the hinge region, the similar isouronium moiety was computationally, synthetically and biologically studied indicating that an isouronium derivative of 1 will interact in a similar manner with ATP.

Funder

Trinity College Dublin

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C8MD00089A

Reference39 articles.

1. Protein kinases — the major drug targets of the twenty-first century?

2. FDA-approved small-molecule kinase inhibitors

3. A small molecule–kinase interaction map for clinical kinase inhibitors