Allantodapsone is a Pan-Inhibitor of Staphylococcus aureus Adhesion to Fibrinogen, Loricrin, and Cytokeratin 10-Reference-Cited by-同舟云学术

Allantodapsone is a Pan-Inhibitor of Staphylococcus aureus Adhesion to Fibrinogen, Loricrin, and Cytokeratin 10

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Prencipe Filippo¹,Alsibaee Aishah²^ORCID,Khaddem Zainab²,Norton Padraig²,Towell Aisling M.³^ORCID,Ali Afnan F. M.²,Reid Gerard¹,Fleury Orla M.³^ORCID,Foster Timothy J.³^ORCID,Geoghegan Joan A.³⁴^ORCID,Rozas Isabel¹^ORCID,Brennan Marian P.²^ORCID

Affiliation:

1. School of Chemistry, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

2. School of Pharmacy and Biomedical Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland

3. Department of Microbiology, Moyne Institute of Preventive Medicine, School of Genetics and Microbiology, Trinity College Dublin, Dublin, Ireland

4. Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham, United Kingdom

Abstract

S. aureus colonization of the nares and the skin provide a reservoir of bacteria that can be transferred to wounds that can ultimately result in systemic infections. Antibiotic resistance can make these infections difficult to treat with significant associated morbidity and mortality. We have identified and characterized a first-in-class small molecule inhibitor of the S. aureus clumping factors A and B, which has the potential to be developed further as a colonization inhibitor.

Funder

Science Foundation Ireland

British Skin Foundation

MOE | Saudi Arabian Cultural Mission

Kuwaiti Cultural Office

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01175-21

Reference38 articles.