Synthesis and cholinesterase inhibitory activity study of Amaryllidaceae alkaloid analogues with <i>N</i>-methyl substitution-Reference-Cited by-同舟云学术

Synthesis and cholinesterase inhibitory activity study of Amaryllidaceae alkaloid analogues with N-methyl substitution

Published:2022 Issue:19 Volume:20 Page:3960-3966
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Jansa Petr¹,Barvík Ivan²^ORCID,Hulcová Daniela³^ORCID,Matoušová Eliška¹^ORCID

Affiliation:

1. Department of Organic Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 00 Praha 2, Czech Republic

2. Faculty of Mathematics and Physics, Institute of Physics, Charles University, Ke Karlovu 2026/5, 121 16 Praha 2, Czech Republic

3. Department of Pharmacognosy, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

Abstract

Amaryllidaceae alkaloid analogues were synthesised, including quaternary ammonium derivatives and N-oxides, and their cholinesterase inhibitory activity was investigated in vitro and by molecular docking.

Funder

Univerzita Karlova v Praze

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00553K

Reference27 articles.

1. Phytochemical and biological investigations of Amaryllidaceae alkaloids: a review

2. Alkaloids fromZephyranthes robustaBakerand Their Acetylcholinesterase- and Butyrylcholinesterase-Inhibitory Activity

3. In vitro anticholinesterase, antimonoamine oxidase and antioxidant properties of alkaloid extracts from kola nuts (Cola acuminata and Cola nitida)

4. Acetylcholinesterase Enzyme Inhibitory Effects of Amaryllidaceae Alkaloids

5. A Review of Butyrylcholinesterase as a Therapeutic Target in the Treatment of Alzheimer’s Disease

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