Withapubesides A–D: natural inducible nitric oxide synthase (iNOS) inhibitors from Physalis pubescens

Author:

Xia Gui-Yang12345,Yao Tie12345,Zhang Bing-Yang1234,Li Yang56789,Kang Ning1234,Cao Shi-Jie1234,Ding Li-Qin1234,Chen Li-Xia56789,Qiu Feng1234ORCID

Affiliation:

1. Tianjin State Key Laboratory of Modern Chinese Medicine and School of Chinese Materia Medica

2. Tianjin University of Traditional Chinese Medicine

3. Tianjin 300193

4. China

5. Department of Natural Products Chemistry

6. School of Traditional Chinese Materia Medica

7. Wuya College of Innovation

8. Key Laboratory of Structure-Based Drug Design & Discovery

9. Ministry of Education

Abstract

Withapubesides A–D (1–4), candidates for the development of iNOS inhibitors, were isolated from Physalis pubescens.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference32 articles.

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2. Natural withanolides: an overview

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4. Antiproliferative Withanolides fromDatura wrightii

5. Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling

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