An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction-Reference-Cited by-同舟云学术

An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction

Published:2018 Issue:8 Volume:16 Page:1287-1296
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Balwe Sandip Gangadhar¹²³⁴,Jeong Yeon Tae¹²³⁴^ORCID

Affiliation:

1. Department of Image Science and Engineering

2. Pukyong National University

3. Busan 608-737

4. Republic of Korea

Abstract

A concise and efficient one-pot synthesis of novel N-fused tricyclic derivatives has been developed by using the Groebke–Blackburn–Bienaymé (GBB) reaction, which involved the reaction of 3-amino-1H-indazoles, aldehydes and isonitriles to afford 2-aryl-5H-imidazo[1,2-b]indazol-3-amine derivatives via a formal [4 + 1] cycloaddition reaction.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C7OB02933K

Reference82 articles.

1. Novel Trisubstituted Benzimidazoles, Targeting Mtb FtsZ, as a New Class of Antitubercular Agents

2. Antitumor Activity of New Substituted 3-(5-Imidazo[2,1-b]thiazolylmethylene)-2-indolinones and Study of Their Effect on the Cell Cycle

3. Pyrrolo[1,5]benzoxa(thia)zepines as a New Class of Potent Apoptotic Agents. Biological Studies and Identification of an Intracellular Location of Their Drug Target

4. The first catalyst and solvent-free synthesis of 2-arylimidazo[2,1-b][1,3,4]thiadiazoles: a comparative assessment of greenness

5. Synthetic Approaches to the New Drugs Approved During 2015

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