Divergent synthesis of pyrrolidone fused pyrimido[1,2-<i>b</i>]indazole through selective trapping of an enone intermediate by 1<i>H</i>-indazol-3-amine-Reference-Cited by-同舟云学术

Divergent synthesis of pyrrolidone fused pyrimido[1,2-b]indazole through selective trapping of an enone intermediate by 1H-indazol-3-amine

Published:2024 Issue:72 Volume:60 Page:9781-9784
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Shen Xi¹,Yu Zhi-Cheng¹,Zhou You¹^ORCID,Wu Yan-Dong¹,Wu An-Xin¹²^ORCID

Affiliation:

1. National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China

2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China

Abstract

An oxidant-controlled divergent synthesis of a pyrrolidone fused pyrimido[1,2-b]indazole skeleton was developed through selective cyclization of an in situ generated enone intermediate and 1H-indazol-3-amine.

Funder

National Natural Science Foundation of China

Higher Education Discipline Innovation Project

Chengdu Science and Technology Bureau

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC03483J

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1. Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens

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3. Lamellarins and Related Pyrrole-Derived Alkaloids from Marine Organisms

4. Synthesis, molecular dynamic, and in silico study of new ethyl 4-arylpyrimido[1,2-b]indazole-2-carboxylate: Potential inhibitors of α-glucosidase

5. GdCl3 catalysed Grieco condensation: A facile approach for the synthesis of novel pyrimidine and annulated pyrimidine fused indazole derivatives in single pot under mild conditions and their anti-microbial activity