Five and six membered heterocyclic rings endowed with azobenzene as dual EGFR<sup>T790M</sup> and VEGFR-2 inhibitors: design, synthesis, <i>in silico</i> ADMET profile, molecular docking, dynamic simulation and anticancer evaluations-Reference-Cited by-同舟云学术

Five and six membered heterocyclic rings endowed with azobenzene as dual EGFR^T790M and VEGFR-2 inhibitors: design, synthesis, in silico ADMET profile, molecular docking, dynamic simulation and anticancer evaluations

Published:2023 Issue:50 Volume:13 Page:35321-35338
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Anwer Kurls E.¹,El-Hddad Sanadelaslam S. A.²^ORCID,Abd El-Sattar Nour E. A.¹³^ORCID,El-morsy Ahmed⁴,Khedr Fathalla⁵,Mohamady Samy⁶,Keshek Doaa E.⁷⁸,Salama Samir A.⁹,El-Adl Khaled⁵¹⁰^ORCID,Hanafy Noura S.¹⁰

Affiliation:

1. Department of Chemistry, Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt

2. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Omar Almukhtar University, Libya

3. Basic & Medical Sciences Department, Faculty of Dentistry, Alryada University for Science & Technology, Egypt

4. Pharmaceutical Chemistry Department, College of Pharmacy, The Islamic University, Najaf, Iraq

5. Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11884, Cairo, Egypt

6. Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt

7. Department of Biology, Jumum College University, Umm Al-Qura University, P.O. Box 7388, Makkah 21955, Sudia Arabia

8. Agriculture Genetic Engineering Research Institute (AGERI), Agriculture Research Centre, Giza, Egypt

9. Division of Biochemistry, Department of Pharmacology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Kingdom of Saudi Arabia

10. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt

Abstract

Novel azobenzene scaffold-joined heterocyclic isoxazole, pyrazole, triazole, and/or triazine moieties have been developed and synthesized utilizing microwave and traditional methods.

Funder

Taif University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA06614B

Reference64 articles.

1. Molecular hybridization approach for phenothiazine incorporated 1,2,3-triazole hybrids as promising antimicrobial agents: Design, synthesis, molecular docking and in silico ADME studies

2. Tandem chalcone-sulfonamide hybridization, cyclization and further Claisen–Schmidt condensation: Tuning molecular diversity through reaction time and order and catalyst

3. Synthesis, biological evaluation, and in silico studies of novel chalcone- and pyrazoline-based 1,3,5-triazines as potential anticancer agents

4. New Benzimidazole-, 1,2,4-Triazole-, and 1,3,5-Triazine-Based Derivatives as Potential EGFR^WT and EGFR^T790M Inhibitors: Microwave-Assisted Synthesis, Anticancer Evaluation, and Molecular Docking Study

5. New series of isoxazole derivatives targeting EGFR-TK: Synthesis, molecular modeling and antitumor evaluation