Synthesis and antiviral evaluation of base-modified deoxythreosyl nucleoside phosphonates-Reference-Cited by-同舟云学术

Synthesis and antiviral evaluation of base-modified deoxythreosyl nucleoside phosphonates

Published:2017 Issue:26 Volume:15 Page:5513-5528
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Liu Chao¹²³⁴⁵,Dumbre Shrinivas G.¹²³⁴⁵,Pannecouque Christophe¹²⁶⁷⁴,Korba Brent⁸⁶⁹¹⁰,De Jonghe Steven¹²³⁴⁵,Herdewijn Piet¹²³⁴⁵^ORCID

Affiliation:

1. KU Leuven

2. Rega Institute for Medical Research

3. Medicinal Chemistry

4. 3000 Leuven

5. Belgium

6. Department of Microbiology and Immunology

7. Laboratory of Virology and Chemotherapy

8. Georgetown University Medical Center

9. Washington

10. USA

Abstract

Base modified l-α-2′-deoxythreosyl nucleoside phosphonates and their phosphonodiamidate prodrugs were synthesized and evaluated for their inhibitory activity against HIV and HBV.

Funder

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01265A

Reference29 articles.

1. Acyclic nucleoside phosphonates: a key class of antiviral drugs

2. Medicinal Chemistry of Nucleoside Phosphonate Prodrugs for Antiviral Therapy

3. Clinical Potential of the Acyclic Nucleoside Phosphonates Cidofovir, Adefovir, and Tenofovir in Treatment of DNA Virus and Retrovirus Infections

4. Regiospecific and highly stereoselective electrophilic addition to furanoid glycals: synthesis of phosphonate nucleotide analogs with potent activity against HIV

5. Design and Profiling of GS-9148, a Novel Nucleotide Analog Active against Nucleoside-Resistant Variants of Human Immunodeficiency Virus Type 1, and Its Orally Bioavailable Phosphonoamidate Prodrug, GS-9131

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