Acyclic nucleoside phosphonates: a key class of antiviral drugs
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd1877.pdf
Reference154 articles.
1. De Clercq, E. et al. A novel selective broad-spectrum anti-DNA virus agent. Nature 323, 464–467 (1986). First description of a unique class of antiviral agents represented by ( S )-9-(3-hydroxyl-2-phosphonylmethoxypropyl)adenine and PMEA (adefovir), which would later be used (as Hepsera) for the treatment of chronic hepatitis B.
2. De Clercq, E. et al. Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines. Antiviral Res. 8, 261–272 (1987). First description of the antiviral activity of ( S )-1-(3-hydroxyl-2-phosphonyl-methoxypropyl)cytosine, which nine years later would be launched (as Vistide) for the treatment of CMV in AIDS patients.
3. Snoeck, R., Sakuma, T., De Clercq, E., Rosenberg, I. & Holý, A. (S)-1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication. Antimicrob. Agents Chemother. 32, 1839–1844 (1988).
4. Balzarini, J. et al. Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent. Proc. Natl Acad. Sci. USA 86, 332–336 (1989). First description of in vivo antiretroviral activity of PMEA in a murine retrovirus (Moloney sarcoma virus) model, which would subsequently serve as the experimental model for demonstrating in vivo antiretroviral activity of R -PMPA (tenofovir).
5. Pauwels, R. et al. Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents. Antimicrob. Agents Chemother. 32, 1025–1030 (1988).
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