Synthesis and biological evaluation of imidazo[1,5-a]pyridine-benzimidazole hybrids as inhibitors of both tubulin polymerization and PI3K/Akt pathway

Author:

Kamal Ahmed12345,Rao A. V. Subba123,Nayak V. Lakshma123,Reddy N. V. Subba123,Swapna Konderu456,Ramakrishna G.123,Alvala Mallika456

Affiliation:

1. Medicinal Chemistry & Pharmacology

2. CSIR-Indian Institute of Chemical Technology

3. Hyderabad 500 007, India

4. Department of Medicinal Chemistry

5. National Institute of Pharmaceutical Education and Research (NIPER)

6. Hyderabad-500 037, India

Abstract

Imidazo[1,5-a]pyridine-benzimidazole hybrids are firstly reported herein to induce cytotoxicity by targeting microtubules.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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