Synthesis and biological evaluation of imidazo[1,5-a]pyridine-benzimidazole hybrids as inhibitors of both tubulin polymerization and PI3K/Akt pathway
Author:
Affiliation:
1. Medicinal Chemistry & Pharmacology
2. CSIR-Indian Institute of Chemical Technology
3. Hyderabad 500 007, India
4. Department of Medicinal Chemistry
5. National Institute of Pharmaceutical Education and Research (NIPER)
6. Hyderabad-500 037, India
Abstract
Imidazo[1,5-a]pyridine-benzimidazole hybrids are firstly reported herein to induce cytotoxicity by targeting microtubules.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB01930J
Reference69 articles.
1. Microtubule structure and its stabilisation
2. Microtubule dynamics and tubulin interacting proteins
3. Microtubules as a target for anticancer drugs
4. Refined structure of αβ-tubulin at 3.5 Å resolution 1 1Edited by I. A. Wilson
5. Structural basis for the regulation of tubulin by vinblastine
Cited by 39 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Electrochemical synthesis of CN-substituted imidazo[1,5-a]pyridines via a cascade process using NH4SCN as both an electrolyte and a non-trivial cyanating agent;Organic Chemistry Frontiers;2024
2. Construction of Imidazole-Fused-Ring Systems by Iron-Catalyzed C(sp3)-H Amination–Cyclization under Aerobic Conditions;The Journal of Organic Chemistry;2023-11-17
3. Impact of Benzimidazole Containing Scaffolds as Anticancer Agents through Diverse Modes of Action;Current Bioactive Compounds;2023-11
4. Divergent Synthesis of Pyrazolo[1,5-a]pyridines and Imidazo[1,5-a]pyridines via Reagent-Controlled Cleavage of the C–N or C–C Azirine Bond in 2-Pyridylazirines;Organic Letters;2023-09-22
5. Divalent metal complexes of N,O- and N,N-bidentate imidazo[1,5-a]pyridine ligands: Synthesis, crystal structures, and photophysical properties;Inorganica Chimica Acta;2023-09
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3