Insights into the initial stages of lipid-mediated haemozoin nucleation

Author:

Kuter David123,Mohunlal Roxanne456,Fitzroy Sharné-Maré123,Asher Constance456,Smith Peter J.78910,Egan Timothy J.456,de Villiers Katherine A.123ORCID

Affiliation:

1. Department of Chemistry and Polymer Science

2. Stellenbosch University

3. Matieland 7602, South Africa

4. Department of Chemistry

5. University of Cape Town

6. Rondebosch 7701, South Africa

7. Division of Pharmacology

8. Department of Medicine

9. University of Cape Town Medical School

10. Observatory 7925, South Africa

Abstract

Lipid-mediated haemozoin nucleation, as probed by molecular dynamics, proceeds via aggregation of ferrihaem π–π dimers at a lipid–aqueous interface.

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

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