Adsorption to the Surface of Hemozoin Crystals: Structure‐Based Design and Synthesis of Amino‐Phenoxazine β‐Hematin Inhibitors-Reference-Cited by-同舟云学术

Adsorption to the Surface of Hemozoin Crystals: Structure‐Based Design and Synthesis of Amino‐Phenoxazine β‐Hematin Inhibitors

Published:2022-04-26 Issue:10 Volume:17 Page:
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Olivier Tania¹,Loots Leigh¹,Kok Michélle²,Villiers Marianne²^ORCID,Reader Janette³,Birkholtz Lyn‐Marié³^ORCID,Arnott Gareth E.¹^ORCID,Villiers Katherine A.¹^ORCID

Affiliation:

1. Department of Chemistry and Polymer Science Stellenbosch University Private BagX1 Matieland 7602 South Africa

2. Department of Biochemistry Stellenbosch University Private BagX1 Matieland 7602 South Africa

3. Department of Biochemistry, Genetics and Microbiology Institute for Sustainable Malaria Control University of Pretoria Pretoria 0028 South Africa

Funder

National Institutes of Health

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202200139

Reference81 articles.

1. The global fight against malaria is at crossroads

2. World Malaria Report 2021 World Health Organization 2021. (https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2021).

4. Haemozoin (malaria pigment): a unique crystalline drug target

5. Unraveling heme detoxification in the malaria parasite by in situ correlative X-ray fluorescence microscopy and soft X-ray tomography

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