Automated flow and real-time analytics approach for screening functional group tolerance in heterogeneous catalytic reactions

Author:

Simon Kevin12ORCID,Sagmeister Peter12ORCID,Munday Rachel3,Leslie Kevin3,Hone Christopher A.12ORCID,Kappe C. Oliver12ORCID

Affiliation:

1. Center for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering (RCPE), Inffeldgasse 13, 8010 Graz, Austria

2. Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria

3. Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, UK

Abstract

An automated continuous flow and real-time analytics platform facilitates the generation of quantitative data to understand the sensitivity of the reaction performance in the presence of different functional groups and heterocycles.

Funder

Österreichische Forschungsför-derungsgesellschaft

Bundesministerium für Digitalisierung und Wirtschaftsstandort

Steirische Wirtschaftsför-derungsgesellschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

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