Fe-catalyzed hydroxytrifluoromethylation of α-(trifluoromethyl)styrenes with CF<sub>3</sub>SO<sub>2</sub>Na: facile access to α,β-bistrifluoromethyl tertiary alcohols-Reference-Cited by-同舟云学术

Fe-catalyzed hydroxytrifluoromethylation of α-(trifluoromethyl)styrenes with CF₃SO₂Na: facile access to α,β-bistrifluoromethyl tertiary alcohols

Published:2022 Issue:47 Volume:20 Page:9302-9306
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zheng Pai¹,Liu Chuan¹,Zeng Qianding¹,Zhang Yi¹,Liu Ying¹,He Jingjing¹,Deng Yupian¹,Cao Song¹²^ORCID

Affiliation:

1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology (ECUST), Shanghai, 200237, China

2. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China

Abstract

A practical Fe-catalyzed hydroxytrifluoromethylation of α-(trifluoromethyl)styrenes with CF3SO2Na in the presence of K2S2O8 and air was developed. A variety of α,β-bistrifluoromethyl tertiary alcohols were synthesized in good to excellent yields.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB02035A

Reference41 articles.

1. Visible‐Light‐Induced ortho ‐Selective Migration on Pyridyl Ring: Trifluoromethylative Pyridylation of Unactivated Alkenes

2. Visible-Light-Induced Trifluoromethylation of Allylic Alcohols

3. A metal-free picolinamide assisted electrochemical ortho-trifluoromethylation of arylamines

4. Application of Langlois’ reagent (NaSO2CF3) in C–H functionalisation

5. Copper-Catalyzed Three-Component Oxytrifluoromethylation of Alkenes with Sodium Trifluoromethanesulfinate and Hydroxamic Acid

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