Molecular dynamics simulations and MM-GBSA reveal novel guanosine derivatives against SARS-CoV-2 RNA dependent RNA polymerase-Reference-Cited by-同舟云学术

Molecular dynamics simulations and MM-GBSA reveal novel guanosine derivatives against SARS-CoV-2 RNA dependent RNA polymerase

Published:2022 Issue:5 Volume:12 Page:2741-2750
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Elfiky Abdo A.¹^ORCID,Mahran Hanan A.¹,Ibrahim Ibrahim M.¹,Ibrahim Mohamed N.²³,Elshemey Wael M.¹⁴

Affiliation:

1. Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt

2. Clinical Laboratories Department, College of Applied Medical Sciences, Jouf University, Sakakah, Kingdom of Saudi Arabia

3. Microbiology Department, Faculty of Science, Ain Shams University, Cairo, Egypt

4. Physics Department, Faculty of Science, Islamic University in Madinah, KSA

Abstract

According to the World Health Organization (WHO), SARS-CoV-2 is responsible for more than 5 M deaths and is reported in 223 countries infecting +250 M people.

Funder

Cairo University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D1RA07447D

Reference53 articles.

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4. Quantitative structure-activity relationship and molecular docking revealed a potency of anti-hepatitis C virus drugs against human corona viruses

5. Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease

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