LZY3016, a novel geldanamycin derivative, inhibits tumor growth in an MDA-MB-231 xenograft model-Reference-Cited by-同舟云学术

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LZY3016, a novel geldanamycin derivative, inhibits tumor growth in an MDA-MB-231 xenograft model

Published:2023 Issue:20 Volume:13 Page:13586-13591
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Li Zhenyu¹^ORCID,Jia Lejiao²,Tang Hui¹,Shen Yuemao³,Shen Chengwu¹^ORCID

Affiliation:

1. Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, P. R. China

2. Department of Pharmacy, Cheeloo College of Medicine, Shandong University Qilu Hospital, No. 107 West Wenhua Road, Jinan 250012, Shandong, P. R. China

3. Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, No. 44 West Wenhua Road, Jinan 250012, Shandong, P. R. China

Abstract

Compared to 17-AAG, LZY3016 exhibited higher Hsp90 inhibitory activityin vitroand antitumor activity in MDA-MB-231 xenograft nude mice.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA02131A

Reference25 articles.

1. GELDANAMYCIN, A NEW ANTIBIOTIC

2. Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

3. Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent

4. A phase II trial of 17-(Allylamino)-17-demethoxygeldanamycin in patients with papillary and clear cell renal cell carcinoma

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