Synthesis and biological evaluation of geldanamycin–ferulic acid conjugate as a potent Hsp90 inhibitor-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of geldanamycin–ferulic acid conjugate as a potent Hsp90 inhibitor

Published:2019 Issue:72 Volume:9 Page:42509-42515
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Li Zhenyu¹²³⁴^ORCID,Jia Lejiao¹⁵⁶⁴,Tang Hui¹²³⁴,Shen Yuemao⁷⁸⁹⁶⁴,Shen Chengwu¹²³⁴^ORCID

Affiliation:

1. Department of Pharmacy

2. Shandong Provincial Hospital Affiliated to Shandong University

3. Jinan 250021

4. P. R. China

5. Shandong University Qilu Hospital

6. Jinan 250012

7. Key Laboratory of Chemical Biology (Ministry of Education)

8. School of Pharmaceutical Sciences

9. Shandong University

Abstract

Compared to 17-AAG, LZY228 exhibited higher Hsp90 inhibitory activity in vitro and better antitumor activity in human breast carcinoma (MDA-MB-231) xenograft nude mice.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA08665J

Reference26 articles.

1. GELDANAMYCIN, A NEW ANTIBIOTIC

2. Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

3. Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent

4. A phase II trial of 17-(Allylamino)-17-demethoxygeldanamycin in patients with papillary and clear cell renal cell carcinoma

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