The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals-Reference-Cited by-同舟云学术

The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals

Published:2020 Issue:2 Volume:7 Page:340-344
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Sun Yu-Tuo¹²³⁴⁵,Zhu Dong-Xing¹²³⁴⁵,Rao Xiaofeng⁶⁷⁸⁹,Xu Ming-Hua¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Drug Research

2. Shanghai Institute of Materia Medica

3. Chinese Academy of Sciences

4. and School of Pharmacy

5. University of Chinese Academy of Sciences

6. Shenzhen Grubbs Institute and Department of Chemistry

7. Southern University of Science and Technology

8. Shenzhen 518055

9. China

Abstract

An effective Rh/chiral diene catalyst system for the highly enantioselective synthesis of chiral benzosultams bearing trifluoromethylated quaternary carbon stereocenters has been developed.

Funder

Key New Drug Creation and Manufacturing Program

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/QO/C9QO01203F

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