Electrical stimulation of neural-differentiating iPSCs on novel coaxial electroconductive nanofibers-Reference-Cited by-同舟云学术

Electrical stimulation of neural-differentiating iPSCs on novel coaxial electroconductive nanofibers

Published:2021 Issue:15 Volume:9 Page:5359-5382
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Garrudo Fábio F. F.¹²³⁴⁵^ORCID,Nogueira Diogo E. S.⁶⁷⁸⁹¹⁰^ORCID,Rodrigues Carlos A. V.⁶⁷⁸⁹¹⁰^ORCID,Ferreira Flávio A.⁶⁷⁸⁹¹⁰^ORCID,Paradiso Patrizia¹¹⁷⁸¹²¹⁰^ORCID,Colaço Rogério¹¹⁷⁸¹²¹⁰^ORCID,Marques Ana C.¹³¹⁴⁷⁸¹²^ORCID,Cabral Joaquim M. S.⁶⁷⁸⁹¹⁰^ORCID,Morgado Jorge¹⁵⁸⁹¹⁰^ORCID,Linhardt Robert J.¹²³⁴⁵^ORCID,Ferreira Frederico Castelo⁶⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology

2. Department of Chemistry & Chemical Biology

3. Rensselaer Polytechnic Institute

4. Biotechnology Center 4005

5. Troy

6. Department of Bioengineering and iBB – Institute for Bioengineering and Biosciences

7. Instituto Superior Técnico

8. Universidade de Lisboa

9. Lisboa

10. Portugal

11. IDMEC - Instituto de Engenharia Mecânica

12. P-1049-001 Lisboa

13. CERENA

14. DEQ

15. Department of Bioengineering and Instituto de Telecomunicações

Abstract

Coaxial PCL-PANI/PGS fibers are biodegradable and electroconductive (0.063 ± 0.029 S cm⁻¹) for 21 days in PBS. Electrical stimulation of cultured iNPCs (30 days) lead to a dominant excitatory (VGLUT1) neural profile over an inhibitory (GAD67) one.

Funder

National Institutes of Health

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D1BM00503K

Reference113 articles.

1. Deciphering the adult brain development complexity by single-cell transcriptome analysis—a review

2. Bioinspired scaffold induced regeneration of neural tissue