Synergy between 3D-extruded electroconductive scaffolds and electrical stimulation to improve bone tissue engineering strategies

Author:

Silva João C.123ORCID,Marcelino Pedro1234ORCID,Meneses João4ORCID,Barbosa Frederico123ORCID,Moura Carla S.45ORCID,Marques Ana C.67ORCID,Cabral Joaquim M. S.123ORCID,Pascoal-Faria Paula489ORCID,Alves Nuno4109ORCID,Morgado Jorge311ORCID,Ferreira Frederico Castelo123ORCID,Garrudo Fábio F. F.12311ORCID

Affiliation:

1. iBB – Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisboa 1049-001, Portugal

2. Associate Laboratory i4HB – Institute for Health and Bioeconomy, Avenida. Rovisco Pais, Lisboa 1049-001, Portugal

3. Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais, Lisboa 1049-001, Portugal

4. CDRSP – Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, Rua de Portugal-Zona Industrial, Marinha Grande 2430-028, Portugal

5. Research Centre for Natural Resources Environment and Society (CERNAS), Polytechnic Institute of Coimbra, Bencanta, 3045-601 Coimbra, Portugal

6. CERENA, DEQ, Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais, Lisboa 1049-001, Portugal

7. Department of Chemical Engineering, Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais, Lisboa 1049-001, Portugal

8. Department of Mathematics, School of Technology and Management, Polytechnic of Leiria, Morro do Lena—Alto do Vieiro, Apartado 4163, Leiria 2411-901, Portugal

9. Associate Laboratory Arise, Porto, Portugal

10. Department of Mechanical Engineering, School of Technology and Management, Polytechnic of Leiria, Morro do Lena—Alto do Vieiro, Apartado 4163, Leiria 2411-901, Portugal

11. Instituto de Telecomunicações, Instituto Superior Técnico, Universidade de Lisboa, Avenida Rovisco Pais, Lisboa 1049-001, Portugal

Abstract

PCL-PEDOT:PSS electroconductive scaffolds were combined with electrical stimulation to enhance the osteogenic differentiation and mineralization of mesenchymal stem/stromal cells towards improved bone tissue engineering strategies.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

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