Novel class of Bi(iii) hydroxamato complexes: synthesis, urease inhibitory activity and activity against H. pylori-Reference-Cited by-同舟云学术

Novel class of Bi(iii) hydroxamato complexes: synthesis, urease inhibitory activity and activity against H. pylori

Published:2016 Issue:27 Volume:45 Page:11008-11014
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Keogan D. M.¹²³⁴⁵,Twamley B.⁶⁷⁸⁴⁵,Fitzgerald-Hughes D.⁹³¹⁰¹¹¹²,Griffith D. M.¹²³⁴⁵

Affiliation:

1. Centre for Synthesis & Chemical Biology

2. Department of Pharmaceutical & Medicinal Chemistry

3. Royal College of Surgeons in Ireland

4. Dublin 2

5. Ireland

6. School of Chemistry

7. Chemistry Building

8. Trinity College Dublin

9. RCSI Microbiology

10. RCSI Education & Research Centre

11. Beaumont Hospital

12. Dublin 9

Abstract

A novel class of bismuth hydroxamato complexes of type Bi(L_-1H)₂·NO₃ (where L is hydroxamic acid) were specifically designed to and demonstrated to inhibit urease, H. pylori's Achilles heel.

Funder

Irish Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/DT/C5DT05061H

Reference30 articles.

1. Helicobacter pylori virulence factors in gastric carcinogenesis

2. Serum Helicobacter pylori NapA antibody as a potential biomarker for gastric cancer

3. Extragastric Diseases andHelicobacter pylori

4. Acid Acclimation byHelicobacter pylori

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