Affiliation:
1. Laboratory of Membrane Biology, David Geffen School of Medicine at the University of California-Los Angeles and Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California
Abstract
Helicobacter pylori is a Gram-negative neutralophile associated with peptic ulcers and gastric cancer. It has a unique ability to colonize the human stomach by acid acclimation. It uses the pH-gated urea channel, UreI, to enhance urea access to intrabacterial urease and a membrane-anchored periplasmic carbonic anhydrase to regulate periplasmic pH to ~6.1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach.
Publisher
American Physiological Society
Cited by
108 articles.
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