Dithiocarbamation of spiro-aziridine oxindoles: a facile access to C3-functionalised 3-thiooxindoles as apoptosis inducing agents-Reference-Cited by-同舟云学术

Dithiocarbamation of spiro-aziridine oxindoles: a facile access to C3-functionalised 3-thiooxindoles as apoptosis inducing agents

Published:2021 Issue:48 Volume:19 Page:10622-10634
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Sakla Akash P.¹^ORCID,Panda Biswajit²,Laxmikeshav Kritika¹,Soni Jay Prakash¹^ORCID,Bhandari Sonal¹,Godugu Chandraiah²,Shankaraiah Nagula¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad – 500037, India

2. Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad – 500037, India

Abstract

An efficient access to C3-functionalised 3-thiooxindoles has been accomplished via direct dithiocarbamation of spiro-aziridine oxindoles. Their apoptosis-inducing properties have been investigated.

Funder

Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB02102H

Reference53 articles.

1. Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update

2. An insight into medicinal attributes of dithiocarbamates: Bird’s eye view

3. Chemical and Medicinal Versatility of Dithiocarbamates: An Overview

4. Design and synthesis of dithiocarbamate linked β-carboline derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability

5. Dithiocarbamate/piperazine bridged pyrrolobenzodiazepines as DNA-minor groove binders: Synthesis, DNA-binding affinity and cytotoxic activity

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis, crystal structure, Hirshfeld surface analysis, DFT investigation, and molecular docking, of novel organic dithiocarbamates obtained from Baylis-Hillman adducts/alcohols at room temperature;Journal of Molecular Structure;2024-06

2. Regioselective synthesis and in vitro cytotoxicity evaluation of 3-thiooxindole derivatives: Tubulin polymerization inhibition and apoptosis inducing studies;Bioorganic & Medicinal Chemistry;2023-07

3. Synthesis of Oleanolic Acid-Dithiocarbamate Conjugates and Evaluation of Their Broad-Spectrum Antitumor Activities;Molecules;2023-02-02

4. Facile access to S-methyl dithiocarbamates with sulfonium or sulfoxonium iodide as a methylation reagent;Organic & Biomolecular Chemistry;2023

5. Design, synthesis andin vitrocytotoxicity evaluation of indolo–pyrazoles grafted with thiazolidinone as tubulin polymerization inhibitors;RSC Medicinal Chemistry;2023