Design, synthesis and<i>in vitro</i>cytotoxicity evaluation of indolo–pyrazoles grafted with thiazolidinone as tubulin polymerization inhibitors-Reference-Cited by-同舟云学术

Design, synthesis andin vitrocytotoxicity evaluation of indolo–pyrazoles grafted with thiazolidinone as tubulin polymerization inhibitors

Published:2023 Issue:3 Volume:14 Page:549-562
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Soni Jay Prakash¹^ORCID,Chilvery Shrilekha²,Sharma Anamika²,Reddy G. Nikitha¹,Godugu Chandraiah²,Shankaraiah Nagula¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, 500036, India

2. Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Balanagar, Hyderabad, 500036, India

Abstract

The present work demonstrates the design and synthesis of new indolo–pyrazole derivatives, their cytotoxic evaluation, tubulin polymerization inhibition, and molecular modeling studies.

Funder

Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D2MD00442A

Reference63 articles.

1. Cancer Statistics, 2021

2. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

3. World Health Organization , Cancer Fact Sheet , https://www.who.int/news-room/fact-sheets/detail/cancer , (accessed May 26th, 2022 )

4. On the Origin of Cancer Metastasis

5. T. A.Martin , L.Ye , A. J.Sanders , J.Lane and W. G.Jiang , Cancer invasion and metastasis: Molecular and cellular perspective, in Madame Curie Bioscience Database (Internet) , Landes Bioscience , Austin (TX) , 2000–2013 , https://www.ncbi.nlm.nih.gov/books/NBK164700/

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A concise review on recent development of indole derivatives for anticancer activities;Journal of the Indian Chemical Society;2024-10

2. Development of chromone-thiazolidine-2,4-dione Knoevenagel conjugates as apoptosis inducing agents;Bioorganic & Medicinal Chemistry Letters;2024-09

3. Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents;Bioorganic Chemistry;2024-02

4. Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets;Pharmacology & Therapeutics;2024-02

5. Development of 3-Indolyl Substituted Phenyl Pyrazolo-Carboxamide Hybrids as Potential Type Ii Vegfr-2 Inhibitors and in Vitro Cytotoxicity Studies;2024