Design, synthesis and bioactivity investigation of tetrandrine derivatives as potential anti-cancer agents-Reference-Cited by-同舟云学术

Design, synthesis and bioactivity investigation of tetrandrine derivatives as potential anti-cancer agents

Published:2018 Issue:7 Volume:9 Page:1131-1141
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Song Junrong¹²³⁴⁵^ORCID,Lan Junjie⁵⁶⁷⁴⁸,Chen Chao⁵⁶⁷⁴⁸,Hu Shengcao⁸⁹⁷⁴¹⁰,Song Jialei⁵⁶⁷⁴⁸,Liu Wulin⁵⁶⁷⁴⁸,Zeng Xueyi⁵⁶⁷⁴⁸,Lou Huayong⁵⁶⁷⁴⁸,Ben-David Yaacov⁵⁶⁷⁴⁸,Pan Weidong¹²³⁴⁵

Affiliation:

1. Guizhou University

2. Huaxi Avenue South

3. Guiyang 550025

4. PR China

5. State Key Laboratory of Functions and Applications of Medicinal Plants

6. Guizhou Medical University

7. Guiyang 550014

8. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and

9. Chinese Academy of Sciences

10. Zunyi Medical University

Abstract

Twenty-four 14-sulfonamide–tetrandrine derivatives were synthesized. Compound23exhibited growth inhibition of MDA-MB-231 cells with an IC₅₀value of 1.18 ± 0.14 μM.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C8MD00125A

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