Novel Sulfonyl-Substituted Tetrandrine Derivatives for Colon Cancer Treatment by Inducing Mitochondrial Apoptosis and Inhibiting PI3K/AKT/mTOR Pathway

Author:

Ling Jie,Li Xiao,Wang Maolin,Zhang Chaozheng,Liu Yilan,Zhang Xin,Liu Changqun,Ren Qing,Zeng Yingjie,Wang Chuanqi,Chen Ying,Sun Chen,Chen Hongyu,Zuo Yi,Deng Yun,Cao Xiujun,Ren Bo,Li Defang,Lu Jun

Publisher

Elsevier BV

Reference113 articles.

1. After stirring at room temperature for 3 h, the reaction was finished by TLC indication. The mixture was quenched with a hydrochloric acid solution (1 N, 3�10 mL), extracted with DCM (3�30 mL), dried over anhydrous sodium sulfate, and filtered. The solvent was removed under reduced pressure. The residue was purified by column chromatography using DCM;Compound 2 was dissolved in DCM (5 mL), followed by adding ethanolamine (27 ?L, 0.21 mmol), pyridine (13 ?L, 0.14 mmol), and DMAP (3 mg, 0.02 mmol)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3