Copper(ii) complexes of 2-methyl-8-hydroxyquinoline and tri/diimine co-ligand: DFT calculations, DNA and BSA binding, DNA cleavage, cytotoxicity and induction of apoptosis-Reference-Cited by-同舟云学术

Copper(ii) complexes of 2-methyl-8-hydroxyquinoline and tri/diimine co-ligand: DFT calculations, DNA and BSA binding, DNA cleavage, cytotoxicity and induction of apoptosis

Published:2021 Issue:17 Volume:45 Page:7578-7593
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Sangeetha Somasundaram¹²³⁴⁵,Ajaykamal Tamilarasan⁶⁷⁸⁵^ORCID,Murali Mariappan¹²³⁴⁵^ORCID

Affiliation:

1. Coordination and Bioinorganic Chemistry Research Laboratory

2. Department of Chemistry

3. National College (Autonomous)

4. Tiruchirappalli 620 001

5. India

6. School of Chemistry

7. Bharathidasan University

8. Tiruchirappalli 620 024

Abstract

Four-coordinate copper(ii) complex cleaves supercoiled ϕX174 RF DNA without reductant while five-coordinate complex cleaves with reductant. The cytotoxicity against cancer cells are higher than cisplatin, less-toxic to normal cells and induce apoptosis.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ00392E

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