Copper(<scp>ii</scp>) complexes of the CuN<sub>4</sub>S core: selective cytotoxicity to cancerous cells, ROS generation and induction of apoptosis-Reference-Cited by-同舟云学术

Copper(ii) complexes of the CuN₄S core: selective cytotoxicity to cancerous cells, ROS generation and induction of apoptosis

Published:2023 Issue:43 Volume:47 Page:20070-20087
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Malakar Kakoli¹^ORCID,Selvakumaran Balasubramaniam²,Murali Mariappan²^ORCID,Arul Prakash Pitchan³,Sangeetha Somasundaram²⁴,Sohtun Winaki P.¹,Jaabir Mohamed Sultan Mohamed³,Velusamy Marappan³^ORCID

Affiliation:

1. Department of Chemistry, North Eastern Hill University, Shillong 793 022, India

2. Coordination and Bioinorganic Chemistry Research Laboratory, Department of Chemistry, National College (Autonomous), Tiruchirappalli 620 001, Tamil Nadu, India

3. Department of Biotechnology and Microbiology, National College (Autonomous), Tiruchirappalli 620 001, Tamil Nadu, India

4. Department of Chemistry, Tamilavel Umamaheswaranar Karanthai Arts College, Thanjavur 613 002, Tamil Nadu, India

Abstract

New copper(ii) complexes display distorted square pyramidal geometry with CuN4S core and bind to CT DNA partial intercalative mode. Cytotoxicity is selective to cancerous cells and causes cell death mostly through the apoptotic mechanism, which produces the most ROS.

Funder

North East Centre for Biological Sciences and Healthcare Engineering, Indian Institute of Technology Guwahati

Department of Biotechnology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D2NJ06170H

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