An operational transformation of 3-carboxy-4-quinolones into 3-nitro-4-quinolones via ipso-nitration using polysaccharide supported copper nanoparticles: synthesis of 3-tetrazolyl bioisosteres of 3-carboxy-4-quinolones as antibacterial agents

Author:

Azad Chandra S.1234ORCID,Narula Anudeep K.1234

Affiliation:

1. “Hygeia” Centre of Excellence in Pharmaceutical Sciences (CEPS)

2. GGS Indraprastha University

3. New Delhi

4. India

Abstract

The 3-nitro-4-quinolones have been synthesized via ipso nitration of 3-carboxy-4-quinolones by chitosan supported Cu nano-particles. The 3-nitro derivatives were converted into their 3-tetrazolyl bioisosteres which showed increased antibacterial activity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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