An operational transformation of 3-carboxy-4-quinolones into 3-nitro-4-quinolones via ipso-nitration using polysaccharide supported copper nanoparticles: synthesis of 3-tetrazolyl bioisosteres of 3-carboxy-4-quinolones as antibacterial agents
Author:
Affiliation:
1. “Hygeia” Centre of Excellence in Pharmaceutical Sciences (CEPS)
2. GGS Indraprastha University
3. New Delhi
4. India
Abstract
The 3-nitro-4-quinolones have been synthesized via ipso nitration of 3-carboxy-4-quinolones by chitosan supported Cu nano-particles. The 3-nitro derivatives were converted into their 3-tetrazolyl bioisosteres which showed increased antibacterial activity.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA26909A
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