Efficient synthesis of benzosultams containing continuous quaternary carbons <i>via</i> trapping active ylides with cyclic <i>N</i>-sulfonyl ketimines-Reference-Cited by-同舟云学术

Efficient synthesis of benzosultams containing continuous quaternary carbons via trapping active ylides with cyclic N-sulfonyl ketimines

Published:2022 Issue:23 Volume:9 Page:6592-6597
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Luo Zhengli¹,Chen Xuwen¹,Xue Jian¹,Deng Yaqi¹,Dong Suzhen¹^ORCID,Liu Shunying¹^ORCID

Affiliation:

1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China

Abstract

A rapid and efficient method for the synthesis of benzosultams containing continuous quaternary carbons in a one pot fashion has been developed with moderate to excellent yields at room temperature under air. The resulting products exhibit good anticancer activity in osteosarcoma cells.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D2QO01409B

Reference47 articles.

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4. Enantioselective Imino-Ene Reaction of N-Sulfonyl Ketimines with Silyl Enol Ethers: Access to Chiral Benzosultams

5. Diastereoselective synthesis of highly functionalized polycyclic benzosultams via tandem cyclisations of cyclic N-sulfonylimines with in situ generated Huisgen 1,4-dipoles

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