Development of a selective and scalable <i>N</i>1-indazole alkylation-Reference-Cited by-同舟云学术

Development of a selective and scalable N1-indazole alkylation

Published:2024 Issue:9 Volume:14 Page:6367-6373
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Wang Jimmy¹^ORCID,Mccreanney Aaron¹^ORCID,Taylor-Young Amelia¹,Fenton Harriet A. M.¹^ORCID,Miah Rayyan¹,Johnson Rebecca A.¹,Clarke James¹,Hopkins Adam¹,Jones Ricky¹,Waddington William¹^ORCID,Fussell Steven J.¹,Badland Matthew¹,Pibworth Benjamin²,Walton Robert¹

Affiliation:

1. Pfizer R&D UK Limited, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK

2. Concept Life Sciences, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK

Abstract

A scalable and selective N1-alkylation of indazoles broad in scope and suitable for manufacturing scale.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA00598H

Reference38 articles.

1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

2. Rings in Drugs

3. Indazoles as indole bioisosteres: synthesis and evaluation of the tropanyl ester and amide of indazole-3-carboxylate as antagonists at the serotonin 5HT3 receptor

4. Pharmacology of benzydamine

5. N-alkylation of indole and pyrroles in dimethyl sulphoxide

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