Development and Scale-Up of a Key Copper-Catalyzed Biaryl Ether Formation for the Multikilogram Synthesis of Emprumapimod
Author:
Affiliation:
1. Pfizer R&D UK Limited, Ramsgate Road, Sandwich, Kent CT13 9NJ, U.K.
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.4c00052
Reference12 articles.
1. aArray Biopharma, Inc. P38 inhibitors and methods of use thereof. WO 2004/078116 A2, 2004.
2. b Pfizer to Discontinue Development Program for PF-07265803 for LMNA-Related Dilated Cardiomyopathy. 2022. https://www.pfizer.com/news/announcements/pfizer-discontinue-development-program-pf-07265803-lmna-related-dilated (accessed 2023 7-Dec-2023).
3. Development of a selective and scalable N1-indazole alkylation
4. Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals
5. Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited
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