Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone basedChlamydia trachomatisinhibitors-Reference-Cited by-同舟云学术

Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone basedChlamydia trachomatisinhibitors

Published:2019 Issue:11 Volume:10 Page:1966-1987
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Kulén Martina¹²³⁴⁵,Núñez-Otero Carlos⁵²³⁴⁶^ORCID,Cairns Andrew G.¹²³⁴⁵,Silver Jim⁵²³⁴⁷,Lindgren Anders E. G.¹²³⁴⁵,Wede Emma⁵²³⁴⁷,Singh Pardeep¹²³⁴⁵,Vielfort Katarina⁵²³⁴⁷,Bahnan Wael⁵²³⁴⁷,Good James A. D.¹²³⁴⁵,Svensson Richard⁸⁹¹⁰¹¹⁴,Bergström Sven⁵²³⁴⁷,Gylfe Åsa⁵²³⁴⁶,Almqvist Fredrik¹²³⁴⁵

Affiliation:

1. Department of Chemistry

2. Umeå University

3. 901 87 Umeå

4. Sweden

5. Umeå Centre for Microbial Research

6. Laboratory for Molecular Infection Medicine Sweden (MIMS)

7. Department of Molecular Biology

8. The Uppsala University Drug Optimization and Pharmaceutical Profiling Platform

9. Department of Pharmacy

10. Uppsala University

11. SE-751 23 Uppsala

Abstract

Methyl sulfonamide substituents effectively improve the pharmacokinetic properties of bicyclic 2-pyridones, a new class ofChlamydia trachomatisinfectivity inhibitors.

Funder

Vetenskapsrådet

Knut and Alice Wallenberg Foundation

Kempestiftelserna

Stiftelsen för Strategisk Forskning

Göran Gustafssons Stiftelse för Naturvetenskaplig och Medicinsk Forskning

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00405J

Reference24 articles.

1. World Health Organization , Global incidence and prevalence of selected curable sexually transmitted infections – 2008, 978 92 4 150383 9, World Health Organization , Geneva, Switzerland , 2012

2. Human chlamydial infections: persistence, prevalence, and outlook for the future

3. Chlamydial metabolism revisited: interspecies metabolic variability and developmental stage-specific physiologic activities

4. Mechanisms of host cell exit by the intracellular bacterium Chlamydia

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery and Structure–Activity Relationships of Novel ssDAF-12 Receptor Modulators;Journal of Medicinal Chemistry;2024-02-28

2. Virtual screening, pharmacokinetics, and molecular dynamics simulations studies to identify potent approved drugs for Chlamydia trachomatis treatment;Future Journal of Pharmaceutical Sciences;2021-10-30

3. A 2-Pyridone Amide Inhibitor of Transcriptional Activity in Chlamydia trachomatis;Antimicrobial Agents and Chemotherapy;2021-04-19

4. Crystal Growth, Single Crystal Structure, and Biological Activity of Thiazolo-Pyridine Dicarboxylic Acid Derivatives;ACS Omega;2020-10-22