Brønsted-acid-catalyzed selective Friedel–Crafts monoalkylation of isatins with indolizines in water

Author:

Guidotti Bruno Boni1234,da Silva Thiago Sabino1234ORCID,Menezes Correia José Tiago1234ORCID,Coelho Fernando1234ORCID

Affiliation:

1. Laboratory of Synthesis of Natural Products and Drugs – Institute of Chemistry

2. University of Campinas

3. Campinas, São Paulo

4. Brazil

Abstract

Controlled Friedel–Crafts monoalkylations of indolizines with isatins have been achieved by using water as the solvent. This is the first organocatalyzed indolizine 1,2-addition reported.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference66 articles.

1. Progress in Heterocyclic Chemistry , ed. G. W. Gribble and J. A. Joule , Elsevier , Oxford , 2003–2016 , vol. 15–28

2. L. D. Quin and J. A.Tyrell , Fundamentals of heterocyclic chemistry: importance in nature and in the synthesis of pharmaceuticals , John Wiley & Sons , New Jersey , 2010

3. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

4. Indolizines II: Search for Potential Oral Hypoglycemic Agents

5. Facile Synthesis of Heterocycles via 2-Picolinium Bromide and Antimicrobial Activities of the Products

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