Molecular Diagnostics

Abstract

This chapter focuses on advances in technologies that have led to a better understanding of the molecular basis of infectious, genetic and oncological diseases. Highly complex technologies, such as microarrays and next-generation sequencing, have resulted in biomarker discoveries that have led to the development of novel therapies and companion diagnostics. Qualitative and quantitative molecular testing continues to be critical in the management of patients with infectious disease, genetic disease and cancer. Drug development strategies that incorporate genomics have required clinical laboratories to be prepared for and routinely test for pharmacogenomic markers that address metabolic and targeted aspects of drug delivery. Clearly, the transition to high-complexity and high-data-throughput technologies will once again revolutionize how we approach diagnostic medicine with respect to patient care.