Identification of potent tricyclic prodrug S1P1 receptor modulators-Reference-Cited by-同舟云学术

Identification of potent tricyclic prodrug S1P1 receptor modulators

Published:2017 Issue:4 Volume:8 Page:725-729
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Marcoux David¹²³,Xiao Hai-Yun¹²³,Murali Dhar T. G.¹²³,Xie Jenny¹²³,Lehman-McKeeman Lois D.¹²³,Wu Dauh-Rurng¹²³,Dabros Marta¹²³,Yang Xiaoxia¹²³,Taylor Tracy L.¹²³,Zhou Xia D.¹²³,Heimrich Elizabeth M.¹²³,Thomas Rochelle¹²³,McIntyre Kim W.¹²³,Shi Hong¹²³,Levesque Paul C.¹²³,Sun Huadong¹²³,Yang Zheng¹²³,Marino Anthony M.¹²³,Cornelius Georgia¹²³,D'Arienzo Celia J.¹²³,Gupta Anuradha⁴⁵⁶,Pragalathan Bala⁴⁵⁶,Rampulla Richard¹²³,Mathur Arvind¹²³,Shen Ding Ren¹²³,Cvijic Mary Ellen¹²³,Salter-Cid Luisa¹²³,Lombardo Louis J.¹²³,Carter Percy H.¹²³,Dyckman Alaric J.¹²³

Affiliation:

1. Bristol-Myers Squibb Company

2. Princeton

3. USA

4. BMS Biocon Research Center

5. Bangalore

6. India

Abstract

Herein, S1P₁ partial agonists with shorter half-life than our previous clinical candidate are reported. The pulmonary and cardiac safety are assessed, issues currently observed with commercial Gilenya.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C6MD00539J

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