Identification and Preclinical Pharmacology of ((1R,3S)-1-Amino-3-((S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials-Reference-Cited by-同舟云学术

Identification and Preclinical Pharmacology of ((1R,3S)-1-Amino-3-((S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials

Published:2019-02-20 Issue:5 Volume:62 Page:2265-2285
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gilmore John L.¹^ORCID,Xiao Hai-Yun¹,Dhar T. G. Murali¹^ORCID,Yang Michael G.¹^ORCID,Xiao Zili¹,Xie Jenny¹,Lehman-McKeeman Lois D.¹,Gong Lei¹,Sun Huadong¹,Lecureux Lloyd¹,Chen Cliff¹,Wu Dauh-Rurng¹,Dabros Marta¹,Yang Xiaoxia¹,Taylor Tracy L.¹,Zhou Xia D.¹,Heimrich Elizabeth M.¹,Thomas Rochelle¹,McIntyre Kim W.¹,Borowski Virna¹,Warrack Bethanne M.¹,Li Yuwen¹,Shi Hong¹,Levesque Paul C.¹,Yang Zheng¹,Marino Anthony M.¹,Cornelius Georgia¹,D’Arienzo Celia J.¹,Mathur Arvind¹,Rampulla Richard¹,Gupta Anuradha¹^ORCID,Pragalathan Bala¹,Shen Ding Ren¹,Cvijic Mary Ellen¹,Salter-Cid Luisa M.¹,Carter Percy H.¹^ORCID,Dyckman Alaric J.¹^ORCID

Affiliation:

1. Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01695

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3. Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis