Surface-decorated nanoliposomal leonurine targets activated fibroblast-like synoviocytes for efficient rheumatoid arthritis therapy-Reference-Cited by-同舟云学术

Surface-decorated nanoliposomal leonurine targets activated fibroblast-like synoviocytes for efficient rheumatoid arthritis therapy

Published:2023 Issue:21 Volume:11 Page:7099-7113
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Meng Shiyu¹,Song Zhiling¹,Tang Zhuang¹,Yang Xiaoxue¹,Xiao Yi¹,Guo Hui²^ORCID,Zhou Kaixiang³,Du Meirong¹⁴,Zhu Yi Zhun¹,Wang Xiaolin¹^ORCID

Affiliation:

1. School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao 999078, China

2. School of Chemical Engineering and Technology, Sun Yat-sen University, Zhuhai 519082, China

3. Center for Advanced Materials Research, Advanced Institute of Natural Sciences, Beijing Normal University at Zhuhai, Zhuhai 519087, P.R. China

4. Lab of Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai 200032, China

Abstract

Construction of HAP-1 peptide-engineered liposomal leonurine (HAP-Lipo@Leo) for efficient treatment of rheumatoid arthritis by downregulating inflammation, halting migration and invasion of activated FLS, and preserving cartilage/bone integrity.

Funder

Fundo para o Desenvolvimento das Ciências e da Tecnologia

Natural Science Foundation of Guangdong Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D3BM00911D

Reference46 articles.

1. Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies