Alkylsulfonylation of alkenes involving copper carbene coupling: access to alkyl

Alkylsulfonylation of alkenes involving copper carbene coupling: access to alkyl–alkyl sulfones

Published:2024 Issue:7 Volume:11 Page:1975-1981
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Peng Chuan-Chong¹,Long Fang¹²,Feng Rui³,Zhang Kai-Yi¹,Liu Jin-Hui¹,Wu Li-Jun¹^ORCID

Affiliation:

1. College of Sciences, Central South University of Forestry and Technology, Changsha 410004, China

2. Department of Hunan Cuisine, ChangSha Commerce & Tourism College, Changsha 410116, China

3. Department of Chemistry, Capital Normal University, Beijing, 100089, China

Abstract

A novel alkyl radical-initiated alkylsulfonylation of alkenes involving copper carbene coupling is developed for the synthesis of various alkyl–alkyl sulfones by employing potassium metabisulphite (K2S2O5) as a connector.

Funder

Scientific Research Foundation of Hunan Provincial Education Department

Hunan Provincial Innovation Foundation for Postgraduate

Natural Science Foundation of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D3QO01817B

Reference68 articles.

1. Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry

2. Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery

3. Conformationally-restricted cyclic sulfones as potent and selective mTOR kinase inhibitors

4. Renal and systemic effects of continued treatment with renin inhibitor remikiren in hypertensive patients with normal and impaired renal function

5. Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Fe-Catalyzed Fluorosulfonylation of Alkenes via Sulfur Dioxide Insertion: Synthesis of Lactam-Functionalized Alkyl Sulfonyl Fluorides;Organic Letters;2024-08-14

2. Electrochemical Sulfonylation/Cyclization of N-Alkenylacrylamides with Sodium Sulfinates or Sulfonyl Hydrazides;The Journal of Organic Chemistry;2024-07-18