Nucleocapsid protein preferentially binds the stem-loop of duplex/quadruplex hybrid that unfolds the quadruplex structure

Author:

Sheng Yaping12345,Cao Bei6789,Ou Mingxi12345,Wang Yu12345,Yuan Siming12345,Zhang Na10111213,Zou Taotao141516179ORCID,Liu Yangzhong12345ORCID

Affiliation:

1. Department of Pharmacy

2. the First Affiliated Hospital of USTC

3. Division of Life Sciences and Medicine

4. Department of Chemistry

5. University of Science and Technology of China

6. Warshel Institute for Computational Biology and General Education Division

7. The Chinese University of Hong Kong

8. Shenzhen

9. P. R. China

10. High Magnetic Field Laboratory

11. Chinese Academy of Sciences

12. Hefei

13. China

14. Guangdong Key Laboratory of Chiral Molecule and Drug Discovery

15. School of Pharmaceutical Sciences

16. Sun Yat-Sen University

17. Guangzhou

Abstract

HIV nucleocapsid protein unfolds the duplex/quadruplex hybrid structure by binding to the stem-loop region, which induces dynamic fluctuation of G-tetrad and K+ ejection.

Funder

National Key R&D Program of China

National Natural Science Foundation of China

Hefei Center for Physical Science and Technology

Guangdong Science and Technology Department

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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