Highly enantioselective access to diketopiperazines via cinchona alkaloid catalyzed Michael additions-Reference-Cited by-同舟云学术

Highly enantioselective access to diketopiperazines via cinchona alkaloid catalyzed Michael additions

Published:2015 Issue:2 Volume:6 Page:1350-1354
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Cabanillas Alejandro¹²³⁴,Davies Christopher D.⁵⁶⁷,Male Louise¹²³⁴,Simpkins Nigel S.¹²³⁴

Affiliation:

1. School of Chemistry

2. University of Birmingham

3. Birmingham

4. B15 2TT UK

5. AstraZeneca

6. Innovative Medicines

7. SK10 4TG UK

Abstract

Alkaloid catalysed additions to triketopiperazines gives products in high yield and er (88 : 12 to 99 : 1), including bridged hydroxy-DKPs via Michael-addition–ring closure.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/SC/C4SC03218G

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