Enantioselective Michael addition of malonates to β,γ-unsaturated α-ketoesters catalysed by Cu(<scp>ii</scp>) complexes bearing binaphthyl–proline hybrid ligands-Reference-Cited by-同舟云学术

Enantioselective Michael addition of malonates to β,γ-unsaturated α-ketoesters catalysed by Cu(ii) complexes bearing binaphthyl–proline hybrid ligands

Published:2023 Issue:8 Volume:21 Page:1764-1770
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yu Shibo¹,Cai Qihang¹,Li Jiahui¹,Yu Tianxu¹,Liang Jiemian¹,Jiao Zilin¹,Yao Chao¹,Li Yue-Ming¹^ORCID

Affiliation:

1. State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China

Abstract

Up to 96% yields and up to 92% ee were achieved in enantioselective Michael addition of malonates to β,γ-unsaturated α-ketoesters catalysed by copper(ii) complexes bearing binaphthyl–proline hybrid ligands.

Funder

Tianjin Research Innovation Project for Postgraduate Students

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D2OB02305A

Reference51 articles.

1. Vinyl sulfones: Synthetic preparations and medicinal chemistry applications

2. Organocatalytic Enantioselective Michael and Hetero-Michael Reactions