Inhibitory effects of Atlantic cod (<i>Gadus morhua</i>) peptides on RANKL-induced osteoclastogenesis <i>in vitro</i> and osteoporosis in ovariectomized mice-Reference-Cited by-同舟云学术

Inhibitory effects of Atlantic cod (Gadus morhua) peptides on RANKL-induced osteoclastogenesis in vitro and osteoporosis in ovariectomized mice

Published:2022 Issue:4 Volume:13 Page:1975-1988
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Yang Meilian¹,Wu Di¹,Cheng Shuzhen¹²,Dong Yu³,Wu Chao¹^ORCID,Wang Zhenyu¹,Du Ming¹^ORCID

Affiliation:

1. School of Food Science and Technology, Collaborative Innovation Center of Seafood Deep Processing, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China

2. Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China

3. Dalian Feide Biological Industry Co., Ltd., Dalian 116085, China

Abstract

Gadus morhua inhibited RANKL-induced osteoclast formation by inhibiting the activation of MAPK and NF-κB pathways and reduced the bone loss caused by estrogen deficiency in OVX-mice, showing potential anti-osteoporosis activity.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D1FO03696C

Reference50 articles.

1. Paracrine and endocrine actions of bone—the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts

2. Postmenopausal Osteoporosis

3. Treatment of Osteoporosis