New chemical and radiochemical routes to [18F]Rho6G-DEG-F, a delocalized lipophilic cation for myocardial perfusion imaging with PET-Reference-Cited by-同舟云学术

New chemical and radiochemical routes to [18F]Rho6G-DEG-F, a delocalized lipophilic cation for myocardial perfusion imaging with PET

Published:2017 Issue:10 Volume:8 Page:1891-1896
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Inkster J. A. H.¹²³⁴⁵^ORCID,Zhang S.¹²³⁴⁵^ORCID,Akurathi V.¹²³⁴⁵^ORCID,Belanger A.⁶³⁴^ORCID,Dubey S.⁶³⁴^ORCID,Treves S. T.⁵³⁴⁶³^ORCID,Packard A. B.¹²³⁴⁵^ORCID

Affiliation:

1. Boston Children's Hospital

2. Division of Nuclear Medicine and Molecular Imaging

3. Boston

4. USA

5. Harvard Medical School

6. Brigham & Women's Hospital

Abstract

Synthesis of the tosyl precursor (2) facilitates automated synthesis of ¹⁸F-labeled rhodamine 6G, a potential PET myocardial perfusion tracer.

Funder

National Institutes of Health

National Heart, Lung, and Blood Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MD/C7MD00326A

Reference24 articles.

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5. Phase II Safety and Clinical Comparison With Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging for Detection of Coronary Artery Disease

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