Cyanine-based [18F]F-C-glycosyl dual imaging probe: synthesis, physico-chemical characterization, in vitro binding evaluation and direct [18F]fluorination

Author:

Vucko Timothé1,Ariztia Julen1,Jouad Kamal1,Chapeau Dylan1,Mourot Benjamin1,Jouan-Hureaux Valérie2,Collet Charlotte34ORCID,Boura Cédric2,Selmeczi Katalin1ORCID,Pellegrini Moïse Nadia1ORCID,Lamandé-Langle Sandrine1ORCID

Affiliation:

1. Université de Lorraine, CNRS, L2CM, F-54000 Nancy, France

2. Université de Lorraine, CNRS, CRAN, F-54000 Nancy, France

3. NancycloTEP, Molecular Imaging Platform, CHRU-Nancy, Université de Lorraine, Nancy, F-54000, France

4. Université de Lorraine, INSERM, U1254 IADI, F-54000 Nancy, France

Abstract

Efficient synthesis of a [18F]F-C-glycosyl dual imaging probe displaying a cyanine for fluorescence imaging (FLI) and a robust [18F]F–C bond for positron emission tomography (PET) imaging.

Funder

Agence Nationale de la Recherche

European Regional Development Fund

Université de Lorraine

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Reference53 articles.

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4. Fluorine-18-Labeled Fluorescent Dyes for Dual-Mode Molecular Imaging

5. Fluorine‐18 Radiolabelling and Photophysical Characteristics of Multimodal PET–Fluorescence Molecular Probes

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