Continuous flow-mode synthesis of (chiral) amines with transaminase: a strategic biocatalytic approach to essential building blocks-Reference-Cited by-同舟云学术

Continuous flow-mode synthesis of (chiral) amines with transaminase: a strategic biocatalytic approach to essential building blocks

Published:2023 Issue:7 Volume:8 Page:1505-1544
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Meersseman Arango Hippolyte¹,van den Biggelaar Ludivine¹,Soumillion Patrice²,Luis Patricia³,Leyssens Tom¹^ORCID,Paradisi Francesca⁴^ORCID,Debecker Damien P.¹^ORCID

Affiliation:

1. Institute of Condensed Matter and Nanosciences (IMCN), Université catholique de Louvain (UCLouvain), Place Louis Pasteur, 1, 1348 Louvain-La-Neuve, Belgium

2. Louvain Institute of Biomolecular Science and Technology (LIBST), Université catholique de Louvain, Place Croix du Sud, 4-5, 1348 Louvain-La-Neuve, Belgium

3. Materials & Process Engineering (iMMC-IMAP), Université catholique de Louvain, Place Sainte Barbe 2, 1348 Louvain-La-Neuve, Belgium

4. Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, Bern, Switzerland

Abstract

Amines, and in particular chiral amines are essential building blocks for the manufacture of active pharmaceutical ingredients. Continuous flow syntheses using immobilized transaminases pave the way to green and intensified production processes.

Funder

Fonds Spéciaux de Recherche

Fondation Francqui - Stichting

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RE/D3RE00210A

Reference234 articles.

1. Biocatalysis in the Pharmaceutical Industry: The Need for Speed

2. Role of Biocatalysis in Sustainable Chemistry