Bilberry extract, its major polyphenolic compounds, and the soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells-Reference-Cited by-同舟云学术

Bilberry extract, its major polyphenolic compounds, and the soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells

Published:2016 Issue:8 Volume:7 Page:3628-3636
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Aichinger G.¹²³⁴,Pahlke G.¹²³⁴,Nagel L. J.¹²³⁴,Berger W.⁵⁶³⁴,Marko D.¹²³⁴

Affiliation:

1. Department of Food Chemistry and Toxicology

2. University of Vienna

3. A-1090 Vienna

4. Austria

5. Department of Medicine I

6. Institute of Cancer Research

Abstract

The soy isoflavone genistein, a bilberry extract as well as some of its polyphenolic compounds antagonize the cytostatic properties of Erlotinib (Tarceva®), a tyrosine kinase inhibiting chemotherapheutic drug.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2016/FO/C6FO00570E

Reference28 articles.

1. Synergistic inhibition of head and neck tumor growth by green tea (−)‐epigallocatechin‐3‐gallate and EGFR tyrosine kinase inhibitor

2. Potentiation of the Effect of Erlotinib by Genistein in Pancreatic Cancer: The Role of Akt and Nuclear Factor-κB

3. Retracted: Genistein enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitors and inhibits nuclear factor kappa B in nonsmall cell lung cancer cell lines

4. A phase II study of isoflavones, erlotinib, and gemcitabine in advanced pancreatic cancer

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