High-performance cation electrokinetic concentrator based on a γ-CD/QCS/PVA composite and microchip for evaluating the activity of P-glycoprotein without any interference from serum albumin-Reference-Cited by-同舟云学术

High-performance cation electrokinetic concentrator based on a γ-CD/QCS/PVA composite and microchip for evaluating the activity of P-glycoprotein without any interference from serum albumin

Published:2024 Issue:1 Volume:24 Page:127-136
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Zhang Runhui¹,Xu Jun¹,Deng Jieqi¹,Ouyang Wei²,Chen Hanren¹,Tang Qing¹,Zheng Shiquan¹,Liu Lihong¹^ORCID

Affiliation:

1. NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China

2. Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA

Abstract

A high-performance CEC is fabricated using γ-CD/QCS/PVA AEM and a microchip. The CEC exhibits excellent performance in evaluating the properties of P-gp by directly stacking and detecting Rho123 from diluted serum without any interference from HAS.

Funder

National Natural Science Foundation of China

Basic and Applied Basic Research Foundation of Guangdong Province

Special Fund Project for Science and Technology Innovation Strategy of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2024/LC/D3LC00831B

Reference43 articles.

1. Effect of benzo[a]pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer

2. Impact of Curcumin-Induced Changes in P-Glycoprotein and CYP3A Expression on the Pharmacokinetics of Peroral Celiprolol and Midazolam in Rats

3. Relationship between Excretion Clearance of Rhodamine 123 and P-Glycoprotein (Pgp) Expression Induced by Representative Pgp Inducers

4. Evaluation of the Modulation of P-glycoprotein (P-gp) on the Intraocular Disposition of its Substrate in Rabbits

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